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Bcl-x(L) mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages
Virulent Mycobacterium tuberculosis (Mtb) triggers necrosis in host Mφ, which is essential for successful pathogenesis. Here we demonstrate that necrosis of Mtb-infected Mφ is dependent on the action of the cytosolic kinase Receptor Interacting Protein 3 (RIPK3) and the mitochondrial Bcl-2 family me...
Autores principales: | Zhao, Xiaomin, Khan, Nargis, Gan, Huixian, Tzelepis, Fanny, Nishimura, Tomoyasu, Park, Seung-Yeol, Divangahi, Maziar, Remold, Heinz G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638669/ https://www.ncbi.nlm.nih.gov/pubmed/28401933 http://dx.doi.org/10.1038/mi.2017.12 |
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