Enhancing the sialylation of recombinant EPO produced in CHO cells via the inhibition of glycosphingolipid biosynthesis

Sialylation regulates the in vivo half-life of recombinant therapeutic glycoproteins, affecting their therapeutic efficacy. Levels of the precursor molecule cytidine monophospho-N-acetylneuraminic acid (CMP-Neu5Ac) are considered a limiting factor in the sialylation of glycoproteins. Here, we show t...

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Detalles Bibliográficos
Autores principales: Kwak, Chan-Yeong, Park, Seung-Yeol, Lee, Chung-Geun, Okino, Nozomu, Ito, Makoto, Kim, Jung Hoe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638827/
https://www.ncbi.nlm.nih.gov/pubmed/29026192
http://dx.doi.org/10.1038/s41598-017-13609-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638827/
https://www.ncbi.nlm.nih.gov/pubmed/29026192
http://dx.doi.org/10.1038/s41598-017-13609-4

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