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Production and evaluation of parathyroid hormone receptor(1) ligands with intrinsic or assembled peroxidase domains
Parathyroid hormone (PTH) can be C-terminally extended without significant affinity loss for the PTH(1) receptor (PTHR(1)). We developed fusion protein ligands with enzymatic activity to probe PTHR(1)s at the cell surface. Two fusion proteins were generated by linking PTH to the N-terminus of either...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638942/ https://www.ncbi.nlm.nih.gov/pubmed/29026164 http://dx.doi.org/10.1038/s41598-017-13548-0 |