Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition

The gluconeogenic enzyme fructose-1,6-bisphosphatase has been proposed as a potential drug target against Leishmania parasites that cause up to 20,000–30,000 deaths annually. A comparison of three crystal structures of Leishmania major fructose-1,6-bisphosphatase (LmFBPase) along with enzyme kinetic...

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Detalles Bibliográficos
Autores principales: Yuan, Meng, Vásquez-Valdivieso, Montserrat G., McNae, Iain W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639204/
https://www.ncbi.nlm.nih.gov/pubmed/28882541
http://dx.doi.org/10.1016/j.jmb.2017.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639204/
https://www.ncbi.nlm.nih.gov/pubmed/28882541
http://dx.doi.org/10.1016/j.jmb.2017.08.010

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