Cargando…
The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice
Histone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of Alzheimer’s disease. Thus, targeting histone acetylation is discussed as a novel approach to treat dementia. The histone acetylation landscape is shaped by chromatin writer and eraser protei...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639246/ https://www.ncbi.nlm.nih.gov/pubmed/28949335 http://dx.doi.org/10.1038/tp.2017.202 |