The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice

Histone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of Alzheimer’s disease. Thus, targeting histone acetylation is discussed as a novel approach to treat dementia. The histone acetylation landscape is shaped by chromatin writer and eraser protei...

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Detalles Bibliográficos
Autores principales: Benito, E, Ramachandran, B, Schroeder, H, Schmidt, G, Urbanke, H, Burkhardt, S, Capece, V, Dean, C, Fischer, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639246/
https://www.ncbi.nlm.nih.gov/pubmed/28949335
http://dx.doi.org/10.1038/tp.2017.202

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