Structure‐Guided Design of Peptides as Tools to Probe the Protein–Protein Interaction between Cullin‐2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases

Cullin RING E3 ubiquitin ligases (CRLs) are large dynamic multi‐subunit complexes that control the fate of many proteins in cells. CRLs are attractive drug targets for the development of small‐molecule inhibitors and chemical inducers of protein degradation. Herein we describe a structure‐guided bio...

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Detalles Bibliográficos
Autores principales: Cardote, Teresa A. F., Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639367/
https://www.ncbi.nlm.nih.gov/pubmed/28776949
http://dx.doi.org/10.1002/cmdc.201700359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639367/
https://www.ncbi.nlm.nih.gov/pubmed/28776949
http://dx.doi.org/10.1002/cmdc.201700359

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