Inhibiting persistent inward sodium currents prevents myotonia

OBJECTIVE: Patients with myotonia congenita have muscle hyperexcitability due to loss‐of‐function mutations in the ClC‐1 chloride channel in skeletal muscle, which causes involuntary firing of muscle action potentials (myotonia), producing muscle stiffness. The excitatory events that trigger myotoni...

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Detalles Bibliográficos
Autores principales: Hawash, Ahmed A., Voss, Andrew A., Rich, Mark M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639374/
https://www.ncbi.nlm.nih.gov/pubmed/28833464
http://dx.doi.org/10.1002/ana.25017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639374/
https://www.ncbi.nlm.nih.gov/pubmed/28833464
http://dx.doi.org/10.1002/ana.25017

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