Lewis Acid Enabled Copper-Catalyzed Asymmetric Synthesis of Chiral β-Substituted Amides

[Image: see text] Here we report that readily available silyl- and boron-based Lewis acids in combination with chiral copper catalysts are able to overcome the reactivity issues of unactivated enamides, known as the least reactive carboxylic acid derivatives, toward alkylation with organomagnesium r...

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Detalles Bibliográficos
Autores principales: Rodríguez-Fernández, Mamen, Yan, Xingchen, Collados, Juan F., White, Paul B., Harutyunyan, Syuzanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639465/
https://www.ncbi.nlm.nih.gov/pubmed/28960071
http://dx.doi.org/10.1021/jacs.7b07344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639465/
https://www.ncbi.nlm.nih.gov/pubmed/28960071
http://dx.doi.org/10.1021/jacs.7b07344

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