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Hydrogen peroxide yields mechanistic insights into human mRNA capping enzyme function
Capping of nascent RNA polymerase II (Pol II) transcripts is required for gene expression and the first two steps are catalyzed by separate 5′ triphosphatase and guanylyltransferase activities of the human capping enzyme (HCE). The cap is added co-transcriptionally, but how the two activities are co...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640233/ https://www.ncbi.nlm.nih.gov/pubmed/29028835 http://dx.doi.org/10.1371/journal.pone.0186423 |