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Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition
KCC2 is a neuron-specific K(+)-Cl(–) cotransporter essential for establishing the Cl(-) gradient required for hyperpolarizing inhibition in the central nervous system (CNS). KCC2 is highly localized to excitatory synapses where it regulates spine morphogenesis and AMPA receptor confinement. Aberrant...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640428/ https://www.ncbi.nlm.nih.gov/pubmed/29028184 http://dx.doi.org/10.7554/eLife.28270 |