Improved production of cytotoxic thailanstatins A and D through metabolic engineering of Burkholderia thailandensis MSMB43 and pilot scale fermentation

Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 through a genome-guided approach. The limited supply of TST-A, due to its low titer in bacterial fermentation, modest stability and very low recovery rate during purif...

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Detalles Bibliográficos
Autores principales: Liu, Xiangyang, Zhu, Hui, Biswas, Sreya, Cheng, Yi-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640593/
https://www.ncbi.nlm.nih.gov/pubmed/29062925
http://dx.doi.org/10.1016/j.synbio.2016.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640593/
https://www.ncbi.nlm.nih.gov/pubmed/29062925
http://dx.doi.org/10.1016/j.synbio.2016.02.002

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