Signatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes

Tumors are composed of an evolving population of cells subjected to tissue-specific selection, which fuels tumor heterogeneity and ultimately complicates cancer driver gene identification. Here, we integrate cancer cell fraction, population recurrence, and functional impact of somatic mutations as s...

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Detalles Bibliográficos
Autores principales: Zapata, Luis, Susak, Hana, Drechsel, Oliver, Friedländer, Marc R., Estivill, Xavier, Ossowski, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640613/
https://www.ncbi.nlm.nih.gov/pubmed/29030609
http://dx.doi.org/10.1038/s41598-017-12888-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640613/
https://www.ncbi.nlm.nih.gov/pubmed/29030609
http://dx.doi.org/10.1038/s41598-017-12888-1

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