Cargando…

Signatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes

Tumors are composed of an evolving population of cells subjected to tissue-specific selection, which fuels tumor heterogeneity and ultimately complicates cancer driver gene identification. Here, we integrate cancer cell fraction, population recurrence, and functional impact of somatic mutations as s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zapata, Luis, Susak, Hana, Drechsel, Oliver, Friedländer, Marc R., Estivill, Xavier, Ossowski, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640613/ https://www.ncbi.nlm.nih.gov/pubmed/29030609 http://dx.doi.org/10.1038/s41598-017-12888-1

Ejemplares similares

Allele balance bias identifies systematic genotyping errors and false disease associations
por: Muyas, Francesc, et al.
Publicado: (2018)

Efficient and flexible Integration of variant characteristics in rare variant association studies using integrated nested Laplace approximation
por: Susak, Hana, et al.
Publicado: (2021)

eDiVA—Classification and prioritization of pathogenic variants for clinical diagnostics
por: Bosio, Mattia, et al.
Publicado: (2019)

Chromatin signatures of cancer
por: Morgan, Marc A., et al.
Publicado: (2015)

Diagnosis of autosomal dominant polycystic kidney disease using efficient PKD1 and PKD2 targeted next-generation sequencing
por: Trujillano, Daniel, et al.
Publicado: (2014)

Selection of Shine-Dalgarno sequences in plastids
por: Drechsel, Oliver, et al.
Publicado: (2011)

miRTrace reveals the organismal origins of microRNA sequencing data
por: Kang, Wenjing, et al.
Publicado: (2018)

Biallelic loss-of-function LACC1/FAMIN Mutations Presenting as Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
por: Rabionet, Raquel, et al.
Publicado: (2019)

Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome
por: Zapata, Luis, et al.
Publicado: (2018)

The rate and spectrum of mosaic mutations during embryogenesis revealed by RNA sequencing of 49 tissues
por: Muyas, Francesc, et al.
Publicado: (2020)

Jitterbug: somatic and germline transposon insertion detection at single-nucleotide resolution
por: Hénaff, Elizabeth, et al.
Publicado: (2015)

Altered oncomodules underlie chromatin regulatory factors driver mutations
por: Frigola, Joan, et al.
Publicado: (2016)

Correction: PeSV-Fisher: Identification of Somatic and Non-Somatic Structural Variants Using Next Generation Sequencing Data
por: Escaramís, Geòrgia, et al.
Publicado: (2013)

PeSV-Fisher: Identification of Somatic and Non-Somatic Structural Variants Using Next Generation Sequencing Data
por: Escaramís, Geòrgia, et al.
Publicado: (2013)

Chromatin conformation signatures of cellular differentiation
por: Fraser, James, et al.
Publicado: (2009)

Chromatin signature of widespread monoallelic expression
por: Nag, Anwesha, et al.
Publicado: (2013)

The Chromatin Signature of Pluripotency: Establishment and Maintenance
por: Di Giammartino, Dafne Campigli, et al.
Publicado: (2016)

The chromatin signatures of enhancers and their dynamic regulation
por: Barral, Amandine, et al.
Publicado: (2023)

A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of Ca(V)2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca(2+) Influx
por: Bahamonde, Maria Isabel, et al.
Publicado: (2015)

Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier
por: Müller, Marisa, et al.
Publicado: (2020)

Universal drivers of cheese microbiomes
por: Reuben, Rine Christopher, et al.
Publicado: (2022)

Editorial: Chromatin Stability and Dynamics: Targeting and Recruitment of Chromatin Modifiers
por: Farrona, Sara, et al.
Publicado: (2021)

Detailed modeling of positive selection improves detection of cancer driver genes
por: Zhao, Siming, et al.
Publicado: (2019)

Targeted next-generation sequencing in steroid-resistant nephrotic syndrome: mutations in multiple glomerular genes may influence disease severity
por: Bullich, Gemma, et al.
Publicado: (2015)

Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
por: Tarbier, Marcel, et al.
Publicado: (2020)

DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes
por: Nothjunge, Stephan, et al.
Publicado: (2017)

Defining the chromatin signature of inducible genes in T cells
por: Lim, Pek S, et al.
Publicado: (2009)

Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition
por: Agirre, E., et al.
Publicado: (2021)

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis
por: Bassaganyas, L, et al.
Publicado: (2013)

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis
por: Bassaganyas, L, et al.
Publicado: (2015)

Chromatin modifying enzymes as modulators of reprogramming
por: Onder, Tamer T., et al.
Publicado: (2012)

Mdm2 as a chromatin modifier
por: Wienken, Magdalena, et al.
Publicado: (2017)

Study of Modified TBA Driver Scheme
por: Elzhov, A V, et al.
Publicado: (1999)

Investigating the effects of additional truncating variants in DNA-repair genes on breast cancer risk in BRCA1-positive women
por: Sepahi, Ilnaz, et al.
Publicado: (2019)

Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection
por: Liu, Aoxing, et al.
Publicado: (2023)

Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin
por: Ocsenas, Oliver, et al.
Publicado: (2022)

Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver
por: Liu, Shuang, et al.
Publicado: (2016)

Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
por: Fadason, Tayaza, et al.
Publicado: (2018)

MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells
por: Sumida, Noriyuki, et al.
Publicado: (2020)

Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment
por: Weng, Matthias K., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_k9hqlo7vvf749f6flhvd028sat