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Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

Establishment of cell polarity in the mammalian embryo is fundamental for the first cell fate decision that sets aside progenitor cells for both the new organism and the placenta. Yet the sequence of events and molecular mechanism that trigger this process remain unknown. Here, we show that de novo...

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Detalles Bibliográficos
Autores principales: Zhu, Meng, Leung, Chuen Yan, Shahbazi, Marta N., Zernicka-Goetz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640629/
https://www.ncbi.nlm.nih.gov/pubmed/29030553
http://dx.doi.org/10.1038/s41467-017-00977-8