Artemisinin Derivatives Target Topoisomerase 1 and Cause DNA Damage in Silico and in Vitro

DNA topoisomerases 1 and 2 are enzymes that maintain DNA topology and play important essential genome functions, including DNA replication and transcription. Aberrant topoisomerases cause genome instability and a wide range of diseases, cancer in particular. Both Topo 1 and 2 are the targets of valu...

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Detalles Bibliográficos
Autores principales: Kadioglu, Onat, Chan, Ariel, Cong Ling Qiu, Alena, Wong, Vincent Kam Wai, Colligs, Vanessa, Wecklein, Sabine, Freund-Henni Rached, Halima, Efferth, Thomas, Hsiao, Wen-Luan Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640709/
https://www.ncbi.nlm.nih.gov/pubmed/29062278
http://dx.doi.org/10.3389/fphar.2017.00711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640709/
https://www.ncbi.nlm.nih.gov/pubmed/29062278
http://dx.doi.org/10.3389/fphar.2017.00711

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