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Artemisinin Derivatives Target Topoisomerase 1 and Cause DNA Damage in Silico and in Vitro
DNA topoisomerases 1 and 2 are enzymes that maintain DNA topology and play important essential genome functions, including DNA replication and transcription. Aberrant topoisomerases cause genome instability and a wide range of diseases, cancer in particular. Both Topo 1 and 2 are the targets of valu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640709/ https://www.ncbi.nlm.nih.gov/pubmed/29062278 http://dx.doi.org/10.3389/fphar.2017.00711 |