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Sarm1 Deletion, but Not Wld(S), Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

Studies with the Wld(S) mutant mouse have shown that axon and synapse pathology in several models of neurodegenerative diseases are mechanistically related to injury-induced axon degeneration (Wallerian degeneration). Crucially, an absence of SARM1 delays Wallerian degeneration as robustly as Wld(S)...

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Detalles Bibliográficos
Autores principales: Gilley, Jonathan, Ribchester, Richard R., Coleman, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640801/
https://www.ncbi.nlm.nih.gov/pubmed/28978465
http://dx.doi.org/10.1016/j.celrep.2017.09.027