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Mutation of the Putative Immunosuppressive Domain of the Retroviral Envelope Glycoprotein Compromises Infectivity

The envelope glycoprotein of diverse endogenous and exogenous retroviruses is considered inherently immunosuppressive. Extensive work mapped the immunosuppressive activity to a highly conserved domain, termed the immunosuppressive domain (ISD), in the transmembrane (TM) subunit of the envelope glyco...

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Detalles Bibliográficos
Autores principales: Eksmond, Urszula, Jenkins, Bryony, Merkenschlager, Julia, Mothes, Walther, Stoye, Jonathan P., Kassiotis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640850/
https://www.ncbi.nlm.nih.gov/pubmed/28814524
http://dx.doi.org/10.1128/JVI.01152-17