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The GlyR Extracellular β8–β9 Loop – A Functional Determinant of Agonist Potency
Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640878/ https://www.ncbi.nlm.nih.gov/pubmed/29062270 http://dx.doi.org/10.3389/fnmol.2017.00322 |