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The GlyR Extracellular β8–β9 Loop – A Functional Determinant of Agonist Potency

Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an...

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Detalles Bibliográficos
Autores principales: Janzen, Dieter, Schaefer, Natascha, Delto, Carolyn, Schindelin, Hermann, Villmann, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640878/
https://www.ncbi.nlm.nih.gov/pubmed/29062270
http://dx.doi.org/10.3389/fnmol.2017.00322

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