Reduced production and uptake of lactate are essential for the ability of WNT5A signaling to inhibit breast cancer cell migration and invasion

Here we investigated the impact of WNT5A signaling on aerobic glycolysis and evaluated its effects on breast cancer cell migration/invasion. WNT5A signaling reduced migration and lactate production and caused selective down-regulation of the glycolytic enzyme phosphofructokinase platelet-type (PFKP)...

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Detalles Bibliográficos
Autores principales: Prasad, Chandra Prakash, Södergren, Katja, Andersson, Tommy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641063/
https://www.ncbi.nlm.nih.gov/pubmed/29069720
http://dx.doi.org/10.18632/oncotarget.17277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641063/
https://www.ncbi.nlm.nih.gov/pubmed/29069720
http://dx.doi.org/10.18632/oncotarget.17277

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