Cargando…

Acquired somatic TP53 or PIK3CA mutations are potential predictors of when polyps evolve into colorectal cancer

Colorectal cancer (CRC) develops from accumulated mutations. However, which gene determines the malignant transformation from adenoma to carcinoma is still uncertain. Fifty-three formalin fixed paraffin-embedded polyps that had pathological findings from patients with hyperplasia, adenomatous, and t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Pi-Yueh, Chen, Jinn-Shiun, Chang, Shih-Cheng, Wang, Mei-Chia, Chang, Nai-Chung, Wen, Ying-Hao, Tsai, Wen-Sy, Liu, Wei-Hsiu, Liu, Hsiu-Ling, Lu, Jang-Jih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641135/ https://www.ncbi.nlm.nih.gov/pubmed/29069792 http://dx.doi.org/10.18632/oncotarget.20376

Ejemplares similares

Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients
por: Chang, Pi-Yueh, et al.
Publicado: (2020)

NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing
por: Chang, Pi-Yueh, et al.
Publicado: (2016)

Somatic alterations of TP53, ERBB2, PIK3CA and CCND1 are associated with chemosensitivity for breast cancers
por: Yang, Libo, et al.
Publicado: (2019)

Prevalence and spectrum of AKT1, PIK3CA, PTEN and TP53 somatic mutations in Chinese breast cancer patients
por: Li, Guoli, et al.
Publicado: (2018)

A Simple and Highly Specific MassARRAY-Based Stool DNA Assay to Prioritize Follow-up Decisions in Fecal Immunochemical Test-Positive Individuals
por: Chang, Pi-Yueh, et al.
Publicado: (2019)

Convergent TP53 loss and evolvability in cancer
por: Mansur, Marcela Braga, et al.
Publicado: (2023)

TP53, SPOP and PIK3CA Genes Status in Prostate Cancer
por: Al Zoubi, Mazhar Salim, et al.
Publicado: (2020)

Mutation screening in non-syndromic hearing loss patients with cochlear implantation by massive parallel sequencing in Taiwan
por: Liu, Wei-Hsiu, et al.
Publicado: (2019)

Immunohistochemical correlates of TP53 somatic mutations in cancer
por: Murnyák, Balázs, et al.
Publicado: (2016)

Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma
por: Wan, Huiying, et al.
Publicado: (2021)

MicroRNA-223 and microRNA-92a in stool and plasma samples act as complementary biomarkers to increase colorectal cancer detection
por: Chang, Pi-Yueh, et al.
Publicado: (2016)

TP53 alterations in relapsed childhood acute lymphoblastic leukemia
por: Yu, Chih‐Hsiang, et al.
Publicado: (2019)

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
por: Chen, Li, et al.
Publicado: (2018)

High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing
por: Kostecka, Anna, et al.
Publicado: (2022)

Prognostic value of KRAS/TP53/PIK3CA in non-small cell lung cancer
por: Zhao, Jiayi, et al.
Publicado: (2019)

Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis
por: AlGabbani, Qwait
Publicado: (2022)

Plasma cell-free tumor DNA, PIK3CA and TP53 mutations predicted inferior endocrine-based treatment outcome in endocrine receptor-positive metastatic breast cancer
por: Chen, Tom Wei-Wu, et al.
Publicado: (2023)

Somatic TP53 variants frequently confound germline testing results
por: Weitzel, Jeffrey N., et al.
Publicado: (2017)

Immunological Role of TP53 Somatic Mutation Classification in Human Cancers
por: Fang, Jianfei, et al.
Publicado: (2023)

Somatic TP53 mutations are preleukemic events in acute lymphoblastic leukemia
por: Chitadze, Guranda, et al.
Publicado: (2023)

Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation
por: Chui, M Herman, et al.
Publicado: (2021)

Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer
por: Choi, Jin Hyuk, et al.
Publicado: (2023)

Significant Prognostic Features and Patterns of Somatic TP53 Mutations in Human Cancers
por: Zhang, Wensheng, et al.
Publicado: (2017)

Droplet digital polymerase chain reaction for detection and quantification of cell-free DNA TP53 target somatic mutations in oral cancer
por: Lin, Li-Han, et al.
Publicado: (2022)

PIK3CA and TP53 mutations predict overall survival of stage II/III colorectal cancer patients
por: Li, A-Jian, et al.
Publicado: (2018)

Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors
por: Thulin, Anna, et al.
Publicado: (2021)

Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial
por: Davies, John R., et al.
Publicado: (2023)

Nonsynonymous variants in MYH9 and ABCA4 are the most frequent risk loci associated with nonsyndromic orofacial cleft in Taiwanese population
por: Peng, Hsiu-Huei, et al.
Publicado: (2016)

Molecular characterization of AML‐MRC reveals TP53 mutation as an adverse prognostic factor irrespective of MRC‐defining criteria, TP53 allelic state, or TP53 variant allele frequency
por: Zhao, Davidson, et al.
Publicado: (2022)

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer
por: Abdeen, Suhaib K., et al.
Publicado: (2018)

Comprehensive analyses of somatic TP53 mutation in tumors with variable mutant allele frequency
por: Cole, Alexander J., et al.
Publicado: (2017)

Somatic Mutations of TP53 and Prognostic Factors for Primary Operable Breast Cancer: Correspondence
por: Sookaromdee, Pathum, et al.
Publicado: (2022)

TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects
por: Ragu, Mohana Eswari, et al.
Publicado: (2023)

Mitigating the Risk of t-MNs Development: TP53 or Not TP53?
por: Tesio, Melania
Publicado: (2023)

The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients
por: Moe, Svein Erik, et al.
Publicado: (2023)

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
por: Leroy, Bernard, et al.
Publicado: (2013)

TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high-grade intraepithelial neoplasia of the cervix
por: Tornesello, Maria Lina, et al.
Publicado: (2014)

Genomic landscape of pathogenic mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Indonesian colorectal cancer
por: Marbun, Vania Myralda Giamour, et al.
Publicado: (2022)

Mutational Landscape and In-Silico Analysis of TP53, PIK3CA, and PTEN in Patients with Breast Cancer from Khyber Pakhtunkhwa
por: Ahmad, Hilal, et al.
Publicado: (2023)

PIK3CA and TP53 Gene Mutations in Human Breast Cancer Tumors Frequently Detected by Ion Torrent DNA Sequencing
por: Bai, Xusheng, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6d9qasdc0pttauhiaj6eho9q1e