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Binase treatment increases interferon sensitivity and apoptosis in SiHa cervical carcinoma cells by downregulating E6 and E7 human papilloma virus oncoproteins

In this study, we determined whether binase, a ribonuclease from Bacillus pumilus, increases interferon sensitivity and apoptosis in SiHa cervical cancer cells infected with high-risk human papilloma virus (HPV) strain 16. Binase treatment increased SiHa cell apoptosis in a time- and concentration-d...

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Detalles Bibliográficos
Autores principales: Mitkevich, Vladimir A., Burnysheva, Ksenia M., Petrushanko, Irina Yu, Adzhubei, Alexei A., Schulga, Alexey A., Chumakov, Peter M., Makarov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641160/
https://www.ncbi.nlm.nih.gov/pubmed/29069817
http://dx.doi.org/10.18632/oncotarget.20199