Cargando…

Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies

Connexins (Cx) are largely represented in the central nervous system (CNS) with 11 Cx isoforms forming intercellular channels. Moreover, in the CNS, Cx43 can form hemichannels (HCs) at non-junctional membrane as does the related channel-forming Pannexin1 (Panx1) and Panx2. Opening of Panx1 channels...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarrouilhe, Denis, Dejean, Catherine, Mesnil, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641369/
https://www.ncbi.nlm.nih.gov/pubmed/29066951
http://dx.doi.org/10.3389/fnmol.2017.00320
_version_ 1783271211575279616
author Sarrouilhe, Denis
Dejean, Catherine
Mesnil, Marc
author_facet Sarrouilhe, Denis
Dejean, Catherine
Mesnil, Marc
author_sort Sarrouilhe, Denis
collection PubMed
description Connexins (Cx) are largely represented in the central nervous system (CNS) with 11 Cx isoforms forming intercellular channels. Moreover, in the CNS, Cx43 can form hemichannels (HCs) at non-junctional membrane as does the related channel-forming Pannexin1 (Panx1) and Panx2. Opening of Panx1 channels and Cx43 HCs appears to be involved in inflammation and has been documented in various CNS pathologies. Over recent years, evidence has accumulated supporting a link between inflammation and cerebral neuropathies (migraine, Alzheimer’s disease (AD), Parkinson’s disease (PD), major depressive disorder, autism spectrum disorder (ASD), epilepsy, schizophrenia, bipolar disorder). Involvement of Panx channels and Cx43 HCs has been also proposed in pathophysiology of neurological diseases and psychiatric disorders. Other studies showed that following inflammatory injury of the CNS, Panx1 activators are released and prolonged opening of Panx1 channels triggers neuronal death. In neuropsychiatric diseases, comorbidities are frequently present and can aggravate the symptoms and make therapeutic management more complex. The high comorbidity between some neuropathies can be partially understood by the fact that these diseases share a common etiology involving inflammatory pathways and Panx1 channels or Cx43 HCs. Thus, anti-inflammatory therapy opens perspectives of targets for new treatments and could have real potential in controlling a cerebral neuropathy and some of its comorbidities. The purpose of this mini review is to provide information of our knowledge on the link between Cx43- and Panx-based channels, inflammation and cerebral neuropathies.
format Online
Article
Text
id pubmed-5641369
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-56413692017-10-24 Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies Sarrouilhe, Denis Dejean, Catherine Mesnil, Marc Front Mol Neurosci Neuroscience Connexins (Cx) are largely represented in the central nervous system (CNS) with 11 Cx isoforms forming intercellular channels. Moreover, in the CNS, Cx43 can form hemichannels (HCs) at non-junctional membrane as does the related channel-forming Pannexin1 (Panx1) and Panx2. Opening of Panx1 channels and Cx43 HCs appears to be involved in inflammation and has been documented in various CNS pathologies. Over recent years, evidence has accumulated supporting a link between inflammation and cerebral neuropathies (migraine, Alzheimer’s disease (AD), Parkinson’s disease (PD), major depressive disorder, autism spectrum disorder (ASD), epilepsy, schizophrenia, bipolar disorder). Involvement of Panx channels and Cx43 HCs has been also proposed in pathophysiology of neurological diseases and psychiatric disorders. Other studies showed that following inflammatory injury of the CNS, Panx1 activators are released and prolonged opening of Panx1 channels triggers neuronal death. In neuropsychiatric diseases, comorbidities are frequently present and can aggravate the symptoms and make therapeutic management more complex. The high comorbidity between some neuropathies can be partially understood by the fact that these diseases share a common etiology involving inflammatory pathways and Panx1 channels or Cx43 HCs. Thus, anti-inflammatory therapy opens perspectives of targets for new treatments and could have real potential in controlling a cerebral neuropathy and some of its comorbidities. The purpose of this mini review is to provide information of our knowledge on the link between Cx43- and Panx-based channels, inflammation and cerebral neuropathies. Frontiers Media S.A. 2017-10-10 /pmc/articles/PMC5641369/ /pubmed/29066951 http://dx.doi.org/10.3389/fnmol.2017.00320 Text en Copyright © 2017 Sarrouilhe, Dejean and Mesnil. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sarrouilhe, Denis
Dejean, Catherine
Mesnil, Marc
Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies
title Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies
title_full Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies
title_fullStr Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies
title_full_unstemmed Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies
title_short Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies
title_sort connexin43- and pannexin-based channels in neuroinflammation and cerebral neuropathies
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641369/
https://www.ncbi.nlm.nih.gov/pubmed/29066951
http://dx.doi.org/10.3389/fnmol.2017.00320
work_keys_str_mv AT sarrouilhedenis connexin43andpannexinbasedchannelsinneuroinflammationandcerebralneuropathies
AT dejeancatherine connexin43andpannexinbasedchannelsinneuroinflammationandcerebralneuropathies
AT mesnilmarc connexin43andpannexinbasedchannelsinneuroinflammationandcerebralneuropathies