Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation

Adoptive cell therapy (ACT) of autologous tumor infiltrating lymphocytes (TIL) is an effective immunotherapy for patients with solid tumors, yielding objective response rates of around 40% in refractory patients with metastatic melanoma. Most clinical centers utilize bulk, randomly isolated TIL from...

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Detalles Bibliográficos
Autores principales: Seliktar-Ofir, Sivan, Merhavi-Shoham, Efrat, Itzhaki, Orit, Yunger, Sharon, Markel, Gal, Schachter, Jacob, Besser, Michal J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641376/
https://www.ncbi.nlm.nih.gov/pubmed/29067023
http://dx.doi.org/10.3389/fimmu.2017.01211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641376/
https://www.ncbi.nlm.nih.gov/pubmed/29067023
http://dx.doi.org/10.3389/fimmu.2017.01211

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