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The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum

Drug addiction is a chronic, debilitating disease that affects millions of people around the world causing a substantial societal burden. Despite decades of research efforts, treatment possibilities remain limited and relapse represents the most treatment-resistant element. Neurosteroid sigma-1 rece...

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Detalles Bibliográficos
Autores principales: Klawonn, Anna M., Nilsson, Anna, Rådberg, Carl F., Lindström, Sarah H., Ericson, Mia, Granseth, Björn, Engblom, David, Fritz, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641388/
https://www.ncbi.nlm.nih.gov/pubmed/29066971
http://dx.doi.org/10.3389/fphar.2017.00714