Non-equivalence of Wnt and R-spondin ligands during Lgr5(+) intestinal stem cell self-renewal

The canonical Wnt/β-catenin signaling pathway governs diverse developmental, homeostatic and pathologic processes. Palmitoylated Wnt ligands engage cell surface Frizzled (Fzd) receptors and Lrp5/6 co-receptors enabling β-catenin nuclear translocation and Tcf/Lef-dependent gene transactivation(1–3)....

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Detalles Bibliográficos
Autores principales: Yan, Kelley S., Janda, Claudia Y., Chang, Junlei, Zheng, Grace X.Y., Larkin, Kathryn A., Luca, Vincent C., Chia, Luis A., Mah, Amanda T., Han, Arnold, Terry, Jessica M., Ootani, Akifumi, Roelf, Kelly, Lee, Mark, Yuan, Jenny, Li, Xiao, Bolen, Christopher R., Wilhelmy, Julie, Davies, Paige S., Ueno, Hiroo, von Furstenberg, Richard J., Belgrader, Phillip, Ziraldo, Solongo B., Ordonez, Heather, Henning, Susan J., Wong, Melissa H., Snyder, Michael P., Weissman, Irving L., Hsueh, Aaron J., Mikkelsen, Tarjei S., Garcia, K. Christopher, Kuo, Calvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641471/
https://www.ncbi.nlm.nih.gov/pubmed/28467820
http://dx.doi.org/10.1038/nature22313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641471/
https://www.ncbi.nlm.nih.gov/pubmed/28467820
http://dx.doi.org/10.1038/nature22313

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