Mitochondrial ATP Depletion Disrupts Caco-2 Monolayer Integrity and Internalizes Claudin 7

Objective: In vivo studies suggest that intestinal barrier integrity is dependent on mitochondrial ATP production. Here, we aim to provide mechanistic support, using an in vitro model mimicking the oxidative in vivo situation. Methods: Human Caco-2 cells were cultured for 10 days in culture flasks o...

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Detalles Bibliográficos
Autores principales: JanssenDuijghuijsen, Lonneke M., Grefte, Sander, de Boer, Vincent C. J., Zeper, Lara, van Dartel, Dorien A. M., van der Stelt, Inge, Bekkenkamp-Grovenstein, Melissa, van Norren, Klaske, Wichers, Harry J., Keijer, Jaap
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641570/
https://www.ncbi.nlm.nih.gov/pubmed/29075202
http://dx.doi.org/10.3389/fphys.2017.00794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641570/
https://www.ncbi.nlm.nih.gov/pubmed/29075202
http://dx.doi.org/10.3389/fphys.2017.00794

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