Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity

Neuronal inclusions of aggregated RNA‐binding protein fused in sarcoma (FUS) are hallmarks of ALS and frontotemporal dementia subtypes. Intriguingly, FUS's nearly uncharged, aggregation‐prone, yeast prion‐like, low sequence‐complexity domain (LC) is known to be targeted for phosphorylation. Her...

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Detalles Bibliográficos
Autores principales: Monahan, Zachary, Ryan, Veronica H, Janke, Abigail M, Burke, Kathleen A, Rhoads, Shannon N, Zerze, Gül H, O'Meally, Robert, Dignon, Gregory L, Conicella, Alexander E, Zheng, Wenwei, Best, Robert B, Cole, Robert N, Mittal, Jeetain, Shewmaker, Frank, Fawzi, Nicolas L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641905/
https://www.ncbi.nlm.nih.gov/pubmed/28790177
http://dx.doi.org/10.15252/embj.201696394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641905/
https://www.ncbi.nlm.nih.gov/pubmed/28790177
http://dx.doi.org/10.15252/embj.201696394

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