Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by motor neuron loss, leading to paralysis and death 2–5 years following disease onset(1). Nearly all ALS patients contain aggregates of the RNA-binding protein TDP-43 in the brain and spinal cord(2)...

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Detalles Bibliográficos
Autores principales: Becker, Lindsay A., Huang, Brenda, Bieri, Gregor, Ma, Rosanna, Knowles, David A., Jafar-Nejad, Paymaan, Messing, James, Kim, Hong Joo, Soriano, Armand, Auburger, Georg, Pulst, Stefan M., Taylor, J. Paul, Rigo, Frank, Gitler, Aaron D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642042/
https://www.ncbi.nlm.nih.gov/pubmed/28405022
http://dx.doi.org/10.1038/nature22038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642042/
https://www.ncbi.nlm.nih.gov/pubmed/28405022
http://dx.doi.org/10.1038/nature22038

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