Room temperature C(sp(2))–H oxidative chlorination via photoredox catalysis

Photoredox catalysis has been developed to achieve oxidative C–H chlorination of aromatic compounds using NaCl as the chlorine source and Na(2)S(2)O(8) as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp(2))–H bonds over C(sp(3))–H bonds. The method has...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Hu, Xile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642143/
https://www.ncbi.nlm.nih.gov/pubmed/29147528
http://dx.doi.org/10.1039/c7sc03010j
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author Zhang, Lei
Hu, Xile
author_facet Zhang, Lei
Hu, Xile
author_sort Zhang, Lei
collection PubMed
description Photoredox catalysis has been developed to achieve oxidative C–H chlorination of aromatic compounds using NaCl as the chlorine source and Na(2)S(2)O(8) as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp(2))–H bonds over C(sp(3))–H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug.
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spelling pubmed-56421432017-11-16 Room temperature C(sp(2))–H oxidative chlorination via photoredox catalysis Zhang, Lei Hu, Xile Chem Sci Chemistry Photoredox catalysis has been developed to achieve oxidative C–H chlorination of aromatic compounds using NaCl as the chlorine source and Na(2)S(2)O(8) as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp(2))–H bonds over C(sp(3))–H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug. Royal Society of Chemistry 2017-10-01 2017-08-15 /pmc/articles/PMC5642143/ /pubmed/29147528 http://dx.doi.org/10.1039/c7sc03010j Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Zhang, Lei
Hu, Xile
Room temperature C(sp(2))–H oxidative chlorination via photoredox catalysis
title Room temperature C(sp(2))–H oxidative chlorination via photoredox catalysis
title_full Room temperature C(sp(2))–H oxidative chlorination via photoredox catalysis
title_fullStr Room temperature C(sp(2))–H oxidative chlorination via photoredox catalysis
title_full_unstemmed Room temperature C(sp(2))–H oxidative chlorination via photoredox catalysis
title_short Room temperature C(sp(2))–H oxidative chlorination via photoredox catalysis
title_sort room temperature c(sp(2))–h oxidative chlorination via photoredox catalysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642143/
https://www.ncbi.nlm.nih.gov/pubmed/29147528
http://dx.doi.org/10.1039/c7sc03010j
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AT huxile roomtemperaturecsp2hoxidativechlorinationviaphotoredoxcatalysis

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