Cargando…
Impact of the structures of macrocyclic Michael acceptors on covalent proteasome inhibition
Molecules that have a reactive functional group within a macrocycle represent a class of covalent inhibitor. The relationship between reactivity and affinity for the target is cooperative and complicated. An understanding and characterization of this class of inhibitor are vital for the development...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642145/ https://www.ncbi.nlm.nih.gov/pubmed/29147522 http://dx.doi.org/10.1039/c7sc02941a |