Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis

Atypical protein kinase Cs (aPKC) are involved in cell cycle progression, tumorigenesis, cell survival and migration in many cancers. We believe that aPKCs play an important role in cell motility of melanoma by regulating cell signaling pathways and inducing epithelial to mesenchymal transition (EMT...

Descripción completa

Detalles Bibliográficos
Autores principales: Ratnayake, Wishrawana S., Apostolatos, André H., Ostrov, David A., Acevedo-Duncan, Mildred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642393/
https://www.ncbi.nlm.nih.gov/pubmed/29048609
http://dx.doi.org/10.3892/ijo.2017.4131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642393/
https://www.ncbi.nlm.nih.gov/pubmed/29048609
http://dx.doi.org/10.3892/ijo.2017.4131

Ejemplares similares