Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling

Phosphodiesterase 10A (PDE10) is a cyclic nucleotide (e.g. cGMP) degrading enzyme highly expressed in the brain striatum where it plays an important role in dopaminergic neurotransmission, but has limited expression and no known physiological function outside the central nervous system. Here we repo...

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Detalles Bibliográficos
Autores principales: Zhu, Bing, Lindsey, Ashley, Li, Nan, Lee, Kevin, Ramirez-Alcantara, Veronica, Canzoneri, Joshua C., Fajardo, Alexandra, Madeira da Silva, Luciana, Thomas, Meagan, Piazza, John T., Yet, Larry, Eberhardt, Brian T., Gurpinar, Evrim, Otali, Dennis, Grizzle, William, Valiyaveettil, Jacob, Chen, Xi, Keeton, Adam B., Piazza, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642477/
https://www.ncbi.nlm.nih.gov/pubmed/29050202
http://dx.doi.org/10.18632/oncotarget.20566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642477/
https://www.ncbi.nlm.nih.gov/pubmed/29050202
http://dx.doi.org/10.18632/oncotarget.20566

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