Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor

The permanent defects in bone growth observed in preclinical studies of hedgehog (Hh) pathway inhibitors were not substantiated in early phase clinical studies of vismodegib in children. Consequently, vismodegib advanced into pediatric trials for malignancies suspected of being driven by aberrant ac...

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Detalles Bibliográficos
Autores principales: Robinson, Giles W., Kaste, Sue C., Chemaitilly, Wassim, Bowers, Daniel C., Laughton, Stephen, Smith, Amy, Gottardo, Nicholas G., Partap, Sonia, Bendel, Anne, Wright, Karen D., Orr, Brent A., Warner, William C., Onar-Thomas, Arzu, Gajjar, Amar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642479/
https://www.ncbi.nlm.nih.gov/pubmed/29050204
http://dx.doi.org/10.18632/oncotarget.20619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642479/
https://www.ncbi.nlm.nih.gov/pubmed/29050204
http://dx.doi.org/10.18632/oncotarget.20619

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