HIF-1α:CRAT:miR-144-3p axis dysregulation promotes osteoarthritis chondrocyte apoptosis and VLCFA accumulation

The functional role(s) of peroxisomes in osteoarthritis remains unclear. We demonstrated that peroxisomal dysfunction in osteoarthritis is responsible for very-long-chain fatty acid (VLCFA) accumulation. Through gene-profiling analyses, we identified CRAT as the gene responsible for this event. CRAT...

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Detalles Bibliográficos
Autores principales: Song, Jinsoo, Kang, Yeon-Ho, Yoon, Sik, Chun, Churl-Hong, Jin, Eun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642483/
https://www.ncbi.nlm.nih.gov/pubmed/29050208
http://dx.doi.org/10.18632/oncotarget.20615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642483/
https://www.ncbi.nlm.nih.gov/pubmed/29050208
http://dx.doi.org/10.18632/oncotarget.20615

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