BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma

The expression of CD47 on the cancer cell surface transmits “don’t eat me” signalling that not only inhibits phagocytosis of cancer cells by phagocytes but also impairs anti-cancer T cell responses. Here we report that oncogenic activation of ERK plays an important role in transcriptional activation...

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Detalles Bibliográficos
Autores principales: Liu, Fen, Jiang, Chen Chen, Yan, Xu Guang, Tseng, Hsin-Yi, Wang, Chun Yan, Zhang, Yuan Yuan, Yari, Hamed, La, Ting, Farrelly, Margaret, Guo, Su Tang, Thorne, Rick F., Jin, Lei, Wang, Qi, Zhang, Xu Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642493/
https://www.ncbi.nlm.nih.gov/pubmed/29050218
http://dx.doi.org/10.18632/oncotarget.17704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642493/
https://www.ncbi.nlm.nih.gov/pubmed/29050218
http://dx.doi.org/10.18632/oncotarget.17704

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