Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing

Mixed adenoneuroendocrine carcinoma (MANEC) in the esophagus is an infrequent but highly malignant cancer with few known genomic alterations. We conducted whole-exome sequencing and whole-genome SNP genotyping for 4-6 tumor subregions and 5-6 adjacent normal tissue sites and 1-3 lymph node metastase...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Wenqing, Liu, Zhen, Lei, Wanjun, Sun, Li, Yang, Haijun, Wang, Yu, Ramdas, Shweta, Dong, Xiao, Xu, Ruiping, Cai, Hong, Li, Jun Z., Ke, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642503/
https://www.ncbi.nlm.nih.gov/pubmed/29050228
http://dx.doi.org/10.18632/oncotarget.18678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642503/
https://www.ncbi.nlm.nih.gov/pubmed/29050228
http://dx.doi.org/10.18632/oncotarget.18678

Ejemplares similares