Cargando…

Acrolein induces mtDNA damages, mitochondrial fission and mitophagy in human lung cells

Acrolein (Acr), a highly reactive unsaturated aldehyde, can cause various lung diseases including asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. We have found that Acr can damage not only genomic DNA but also DNA repair proteins causing repair dysfunction and enhancing cells’...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hsiang-Tsui, Lin, Jing-Heng, Yang, Chun-Hsiang, Haung, Chun-Hao, Weng, Ching-Wen, Maan-Yuh Lin, Anya, Lo, Yu-Li, Chen, Wei-Shen, Tang, Moon-Shong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642564/ https://www.ncbi.nlm.nih.gov/pubmed/29050289 http://dx.doi.org/10.18632/oncotarget.19710

Ejemplares similares

Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells
por: Wang, Hsiang-tsui, et al.
Publicado: (2016)

Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
por: Huang, Hui-Ju, et al.
Publicado: (2021)

Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death
por: Wang, Yi-Ting, et al.
Publicado: (2017)

Role of the mtDNA Mutations and Mitophagy in Inflammaging
por: Dabravolski, Siarhei A., et al.
Publicado: (2022)

Modulation of mitochondrial nucleoid structure during aging and by mtDNA content in Drosophila
por: Wang, Li-jie, et al.
Publicado: (2021)

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations
por: Tam, Zhi Yang, et al.
Publicado: (2015)

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
por: Suissa, Sarit, et al.
Publicado: (2009)

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions
por: Rebelo, Adriana P., et al.
Publicado: (2009)

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats
por: Chimienti, Guglielmina, et al.
Publicado: (2019)

Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells
por: Lee, Hyun-Wook, et al.
Publicado: (2014)

Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway
por: Tsai, Hong-Chieh, et al.
Publicado: (2021)

Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation
por: Lee, Hyun-Wook, et al.
Publicado: (2015)

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart
por: Chimienti, Guglielmina, et al.
Publicado: (2018)

Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy
por: Lee, Tzu-Lin, et al.
Publicado: (2020)

Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression
por: Bao, Dengke, et al.
Publicado: (2019)

Where mtDNA is made
por: LeBrasseur, Nicole
Publicado: (2003)

Melanesian mtDNA Complexity
por: Friedlaender, Jonathan S., et al.
Publicado: (2007)

Enhancing Anticancer Effect of Gefitinib across the Blood–Brain Barrier Model Using Liposomes Modified with One α-Helical Cell-Penetrating Peptide or Glutathione and Tween 80
por: Lin, Kuan-Hung, et al.
Publicado: (2016)

Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
por: Kuo, Chin-Wei, et al.
Publicado: (2023)

Author Correction: Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway
por: Tsai, Hong-Chieh, et al.
Publicado: (2021)

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
por: van Tienen, Florence, et al.
Publicado: (2019)

HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity
por: Sural, Surojit, et al.
Publicado: (2020)

Transmission of Functional, Wild-Type Mitochondria and the Fittest mtDNA to the Next Generation: Bottleneck Phenomenon, Balbiani Body, and Mitophagy
por: Tworzydlo, Waclaw, et al.
Publicado: (2020)

Origins and Evolution of the Etruscans’ mtDNA
por: Ghirotto, Silvia, et al.
Publicado: (2013)

mtDNA in the Pathogenesis of Cardiovascular Diseases
por: Wang, Lili, et al.
Publicado: (2021)

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease
por: Nicholls, Thomas J., et al.
Publicado: (2014)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

MELAS and Kearns–Sayre overlap syndrome due to the mtDNA m. A3243G mutation and large-scale mtDNA deletions
por: Yu, Nian, et al.
Publicado: (2016)

Evidence for a Fourteenth mtDNA-Encoded Protein in the Female-Transmitted mtDNA of Marine Mussels (Bivalvia: Mytilidae)
por: Breton, Sophie, et al.
Publicado: (2011)

Association of circulating MtDNA with CVD in hemodialysis patients and in vitro effect of exogenous MtDNA on cardiac microvascular inflammation
por: Fan, Zhen, et al.
Publicado: (2023)

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

Vitamin D(3) decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy
por: Chen, Yu-Chen, et al.
Publicado: (2021)

Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing
por: Bi, Chongwei, et al.
Publicado: (2023)

Keeping mtDNA in Shape between Generations
por: Stewart, James B., et al.
Publicado: (2014)

MtDNA-maintenance defects: syndromes and genes
por: Viscomi, Carlo, et al.
Publicado: (2017)

The Early Peopling of the Philippines based on mtDNA
por: Arenas, Miguel, et al.
Publicado: (2020)

Evolving mtDNA populations within cells
por: Johnston, Iain G., et al.
Publicado: (2019)

Molecular Mechanisms of mtDNA-Mediated Inflammation
por: De Gaetano, Anna, et al.
Publicado: (2021)

Is the Dinoflagellate Amoebophrya Really Missing an mtDNA?
por: Kayal, Ehsan, et al.
Publicado: (2021)

Genetic Diversity in the mtDNA of Physarum polycephalum
por: Hammar, Freya, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j7sf3758uk61b4mkusup55qhk0