Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity

The RUNX2 transcription factor promotes breast cancer growth and metastasis through interactions with a variety of cofactors that activate or repress target genes. Using a direct drug discovery approach we identified CADD522 as a small molecule that inhibits the DNA binding of the runt box domain pr...

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Detalles Bibliográficos
Autores principales: Kim, Myoung Sook, Gernapudi, Ramkishore, Choi, Eun Yong, Lapidus, Rena G., Passaniti, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642608/
https://www.ncbi.nlm.nih.gov/pubmed/29050333
http://dx.doi.org/10.18632/oncotarget.20200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642608/
https://www.ncbi.nlm.nih.gov/pubmed/29050333
http://dx.doi.org/10.18632/oncotarget.20200

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