A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are important regulators of cellular signaling. Aberrant expression or mutation of RasGRPs results in disease. An analysis of RasGRP1 SNP variants led to the conclusion that the charge of His 212 in RasGRP1 alters...

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Detalles Bibliográficos
Autores principales: Vercoulen, Yvonne, Kondo, Yasushi, Iwig, Jeffrey S, Janssen, Axel B, White, Katharine A, Amini, Mojtaba, Barber, Diane L, Kuriyan, John, Roose, Jeroen P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643099/
https://www.ncbi.nlm.nih.gov/pubmed/28952923
http://dx.doi.org/10.7554/eLife.29002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643099/
https://www.ncbi.nlm.nih.gov/pubmed/28952923
http://dx.doi.org/10.7554/eLife.29002

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