Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers

ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation. However, the functional relationship between these homologs has not been explored. Here, we use ATAC-seq, genome-wide histone...

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Detalles Bibliográficos
Autores principales: Kelso, Timothy W R, Porter, Devin K, Amaral, Maria Luisa, Shokhirev, Maxim N, Benner, Christopher, Hargreaves, Diana C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643100/
https://www.ncbi.nlm.nih.gov/pubmed/28967863
http://dx.doi.org/10.7554/eLife.30506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643100/
https://www.ncbi.nlm.nih.gov/pubmed/28967863
http://dx.doi.org/10.7554/eLife.30506

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