Between-Region Genetic Divergence Reflects the Mode and Tempo of Tumor Evolution

Given the implications of tumor dynamics for precision medicine, there is a need to systematically characterize the mode of evolution across diverse solid tumor types. In particular, methods to infer the role of natural selection within established human tumors are lacking. By simulating spatial tum...

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Detalles Bibliográficos
Autores principales: Sun, Ruping, Hu, Zheng, Sottoriva, Andrea, Graham, Trevor A., Harpak, Arbel, Ma, Zhicheng, Fischer, Jared M., Shibata, Darryl, Curtis, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643198/
https://www.ncbi.nlm.nih.gov/pubmed/28581503
http://dx.doi.org/10.1038/ng.3891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643198/
https://www.ncbi.nlm.nih.gov/pubmed/28581503
http://dx.doi.org/10.1038/ng.3891

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