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Between-Region Genetic Divergence Reflects the Mode and Tempo of Tumor Evolution
Given the implications of tumor dynamics for precision medicine, there is a need to systematically characterize the mode of evolution across diverse solid tumor types. In particular, methods to infer the role of natural selection within established human tumors are lacking. By simulating spatial tum...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643198/ https://www.ncbi.nlm.nih.gov/pubmed/28581503 http://dx.doi.org/10.1038/ng.3891 |