Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

Phosphatidylinositol-3-kinases (PI3K) γ and δ are preferentially enriched in leukocytes, and defects in these signaling pathways have been shown to impair T cell activation. The effects of PI3Kγ and PI3Kδ on alloimmunity remain underexplored. Here, we show that both PI3Kγ (−/−) and PI3Kδ (D910A/D910...

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Detalles Bibliográficos
Autores principales: Uehara, Mayuko, McGrath, Martina M., Ohori, Shunsuke, Solhjou, Zhabiz, Banouni, Naima, Routray, Sujit, Evans, Catherine, DiNitto, Jonathan P., Elkhal, Abdallah, Turka, Laurence A., Strom, Terry B., Tullius, Stefan G., Winkler, David G., Azzi, Jamil, Abdi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643371/
https://www.ncbi.nlm.nih.gov/pubmed/29038423
http://dx.doi.org/10.1038/s41467-017-00982-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643371/
https://www.ncbi.nlm.nih.gov/pubmed/29038423
http://dx.doi.org/10.1038/s41467-017-00982-x

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