A versatile pretargeting approach for tumour-selective delivery and activation of TNF superfamily members

TNFR superfamily (TNFRSF) members have important immunoregulatory functions and are of clear interest for cancer immunotherapy. Various TNFRSF agonists have been clinically evaluated, but have met with limited efficacy and/or toxicity. Recent insights indicate that ‘first-generation’ TNFRSF agonists...

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Detalles Bibliográficos
Autores principales: He, Yuan, van Bommel, Peter E., Samplonius, Douwe F., Bremer, Edwin, Helfrich, Wijnand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643434/
https://www.ncbi.nlm.nih.gov/pubmed/29038485
http://dx.doi.org/10.1038/s41598-017-13530-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643434/
https://www.ncbi.nlm.nih.gov/pubmed/29038485
http://dx.doi.org/10.1038/s41598-017-13530-w

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