Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation

Mammalian haploid embryonic stem cells (haESCs) provide new possibilities for large-scale genetic screens because they bear only one copy of each chromosome. However, haESCs are prone to spontaneous diploidization through unknown mechanisms. Here, we report that a small molecule combination could re...

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Detalles Bibliográficos
Autores principales: Li, Haisen, Guo, Ao, Xie, Zhenfei, Tu, Wanzhi, Yu, Jiali, Wang, Huihan, Zhao, Jian, Zhong, Cuiqing, Kang, Jiuhong, Li, Jinsong, Huang, Shichao, Shen, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643530/
https://www.ncbi.nlm.nih.gov/pubmed/29038567
http://dx.doi.org/10.1038/s41598-017-13471-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643530/
https://www.ncbi.nlm.nih.gov/pubmed/29038567
http://dx.doi.org/10.1038/s41598-017-13471-4

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