Cargando…

Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation

Mammalian haploid embryonic stem cells (haESCs) provide new possibilities for large-scale genetic screens because they bear only one copy of each chromosome. However, haESCs are prone to spontaneous diploidization through unknown mechanisms. Here, we report that a small molecule combination could re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Haisen, Guo, Ao, Xie, Zhenfei, Tu, Wanzhi, Yu, Jiali, Wang, Huihan, Zhao, Jian, Zhong, Cuiqing, Kang, Jiuhong, Li, Jinsong, Huang, Shichao, Shen, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643530/ https://www.ncbi.nlm.nih.gov/pubmed/29038567 http://dx.doi.org/10.1038/s41598-017-13471-4

Ejemplares similares

Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization
por: Guo, Ao, et al.
Publicado: (2017)

Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes
por: Yang, Hui, et al.
Publicado: (2013)

Derivation of haploid embryonic stem cells from mouse embryos
por: Leeb, Martin, et al.
Publicado: (2011)

Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation
por: Zhang, Wenhao, et al.
Publicado: (2020)

Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells
por: Zhang, Hongling, et al.
Publicado: (2021)

Transcriptome profiles and chromatin states in mouse androgenetic haploid embryonic stem cells
por: Zheng, Weisheng, et al.
Publicado: (2023)

Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development
por: Bai, Meizhu, et al.
Publicado: (2019)

CRISPR/Cas9-mediated reporter knock-in in mouse haploid embryonic stem cells
por: Kimura, Yasuyoshi, et al.
Publicado: (2015)

Generation of haploid spermatids from chicken embryonal primordial germ cells
por: Ji, Meng, et al.
Publicado: (2018)

Gene dosage in mammals: characterization of haploid embryonic stem cells
por: Wutz, Anton, et al.
Publicado: (2013)

Delayed DNA replication in haploid human embryonic stem cells
por: Edwards, Matthew M., et al.
Publicado: (2021)

Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells
por: Pettitt, Stephen J., et al.
Publicado: (2017)

Production of double haploid watermelon via maternal haploid induction
por: Tian, Shouwei, et al.
Publicado: (2023)

Collection of homozygous mutant mouse embryonic stem cells arising from autodiploidization during haploid gene trap mutagenesis
por: Yamanishi, Ayako, et al.
Publicado: (2018)

Development of In Vivo Haploid Inducer Lines for Screening Haploid Immature Embryos in Maize
por: Chen, Chen, et al.
Publicado: (2020)

Genome-wide genetic screening with chemically-mutagenized haploid embryonic stem cells
por: Forment, Josep V., et al.
Publicado: (2016)

A fast and efficient size separation method for haploid embryonic stem cells
por: Freimann, Remo, et al.
Publicado: (2017)

Production of haploids and doubled haploids in oil palm
por: Dunwell, Jim M, et al.
Publicado: (2010)

Haploid embryonic stem cells serve as a new tool for mammalian genetic study
por: Shuai, Ling, et al.
Publicado: (2014)

Genetic Exploration of the Exit from Self-Renewal Using Haploid Embryonic Stem Cells
por: Leeb, Martin, et al.
Publicado: (2014)

Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells
por: Yin, Zixi, et al.
Publicado: (2017)

Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts
por: HIRABAYASHI, Masumi, et al.
Publicado: (2017)

Polyploidy of semi-cloned embryos generated from parthenogenetic haploid embryonic stem cells
por: Aizawa, Eishi, et al.
Publicado: (2020)

Genome‐wide screen for anticancer drug resistance in haploid human embryonic stem cells
por: Segal, Emanuel, et al.
Publicado: (2023)

Haploid mouse germ cell precursors from embryonic stem cells reveal Xist activation from a single X chromosome
por: Aizawa, Eishi, et al.
Publicado: (2021)

Regulation of Embryonic Stem Cell Self-Renewal
por: Chen, Guofang, et al.
Publicado: (2022)

In vivo maternal haploid induction in tomato
por: Zhong, Yu, et al.
Publicado: (2021)

Current advances in haploid stem cells
por: Cui, Tongtong, et al.
Publicado: (2019)

Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system
por: Horii, Takuro, et al.
Publicado: (2013)

Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens
por: Liu, Guang, et al.
Publicado: (2017)

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog
por: Jin, Jiali, et al.
Publicado: (2016)

Brassica napus Haploid and Double Haploid Production and Its Latest Applications
por: Starosta, Ewa, et al.
Publicado: (2023)

Rapidly generating knockout mice from H19-Igf2 engineered androgenetic haploid embryonic stem cells
por: Zhang, Meili, et al.
Publicado: (2015)

Doubled Haploids in Eggplant
por: Mir, Ricardo, et al.
Publicado: (2021)

The Roads to Haploid Embryogenesis
por: Shen, Kun, et al.
Publicado: (2023)

Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells
por: Bar, Shiran, et al.
Publicado: (2021)

A versatile genetic tool: haploid cells
por: Li, Yanni, et al.
Publicado: (2017)

Protein Kinase Cε Modulates Insulin Receptor Localization and Trafficking in Mouse Embryonic Fibroblasts
por: Pedersen, David J., et al.
Publicado: (2013)

Histone Deacetylase 1 and 3 Regulate the Mesodermal Lineage Commitment of Mouse Embryonic Stem Cells
por: Lv, Weiying, et al.
Publicado: (2014)

An shRNA kinase screen identifies regulators of UHRF1 stability and activity in mouse embryonic stem cells
por: Rushton, Michael D., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rqhup0rfig8l244jl4mu397ani