MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

The breast cancer susceptibility proteins BRCA1 and BRCA2 have emerged as key stabilizing factors for the maintenance of replication fork integrity following replication stress. In their absence, stalled replication forks are extensively degraded by the MRE11 nuclease, leading to chemotherapeutic se...

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Detalles Bibliográficos
Autores principales: Lemaçon, Delphine, Jackson, Jessica, Quinet, Annabel, Brickner, Joshua R., Li, Shan, Yazinski, Stephanie, You, Zhongsheng, Ira, Grzegorz, Zou, Lee, Mosammaparast, Nima, Vindigni, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643552/
https://www.ncbi.nlm.nih.gov/pubmed/29038425
http://dx.doi.org/10.1038/s41467-017-01180-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643552/
https://www.ncbi.nlm.nih.gov/pubmed/29038425
http://dx.doi.org/10.1038/s41467-017-01180-5

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